A new type of synthesis of 1,2,3- Thiadiazole and 1,2,3-diazaphosphole derivatives via-hurd-mori cyclization
Hosny, Mona A.; El-Sayed, Taghreed; El-Sawi, Emtithal A.;
Abstract
We present a short and efficient synthesis of the title compounds starting with cheap and readily available camphor and derivatives of acetophenone. The optimized sequence allows the large-scale preparation of this new type of synthesis in a few steps. New 1, 2,3-thiadiazole and 1,2,3- diazaphosphole derivatives 11-20, were prepared from the ketones 1-5 via the corresponding semicarbazones 6-10. The Hurd-Mori and Lalezari methods were used, respectively, for the preparation of these 1,2,3-thiadiazole and 1,2,3-diazaphosphole derivatives. These derivatives exhibit anticancer effect due to their high potential biological activity.
Other data
Title | A new type of synthesis of 1,2,3- Thiadiazole and 1,2,3-diazaphosphole derivatives via-hurd-mori cyclization | Authors | Hosny, Mona A.; El-Sayed, Taghreed ; El-Sawi, Emtithal A. | Keywords | 1,2,3-diazaphosphole;Semicarbazone;1,2,3-thiadiazole | Issue Date | 13-Apr-2012 | Journal | E-Journal of Chemistry | ISSN | 0973-4945 2090-9810 |
DOI | 10.1155/2012/457949 | Scopus ID | 2-s2.0-84859554933 |
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