Novel, one-pot synthesis of benz-[g]-indenones and 1-tetralones from functionalized 5-membered heterocyclic perchlorates via domino friedel-crafts reactions
El-Sayed, Naglaa F.; Derbala, Hamed A.; Refaee, Mahmoud; Hassan M. F. Madkour;
Abstract
(Z)-4-(Naphth-2-ylmethylene)-2-phenyloxazol-5(4H)-one 1 and 3-(phenylcarbamoyl)-but-3-enoic acid and 3, respectively, are readily transformed into their corresponding perchlorate salts 2 and 4 with acetic anhydrideperchloric acid mixture. Conducting the latter salts with arenes in the presence of AlCl3 provided novel derivatives of benz-[g]-indenones 5 and 1-tetralones 6, respectively, via two consecutive Friedel-Crafts reactions in situ. The structures of all the synthesized products were characterized using IR, 1H NMR, 13C NMR, and mass spectra.
Other data
| Title | Novel, one-pot synthesis of benz-[g]-indenones and 1-tetralones from functionalized 5-membered heterocyclic perchlorates via domino friedel-crafts reactions | Authors | El-Sayed, Naglaa F.; Derbala, Hamed A. ; Refaee, Mahmoud; Hassan M. F. Madkour | Keywords | 1-tetralones;2-phenyloxazol-5(4H)-onium;Benz-[g]-indenones;Friedel-Crafts;Perchlorats | Issue Date | 1-Jan-2016 | Journal | Der Pharma Chemica | Scopus ID | 2-s2.0-84962760941 |
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