Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives
Hassan M. F. Madkour; El-Hashash, Maher Abd El-Aziz Mahmoud; Salem, Marwa Sayed; Mahmoud, Al-Shimaa Omar Ali;
Abstract
Developing novel antileishmanial, and cytotoxic drugs has been a significant area in modern pharmaceutical research. A series of novel triazolo[4,3-a]quinoline, triazino[4,3-a]quinoline, thiadiazepino[5,6-b]quinoline and pyrazolquinoline have been synthesized from the reaction of 2-hydrazinyltetrahydroquinoline-3-carbonitrile with formamide, formic acid, ethyl chloroacetate, carbon disulphide in an alcoholic solution of potassium hydroxide acetyl acetone and/or ethyl cyanoacetate, respectively. These compounds were evaluated for their in vitro studies against L. major leishmanial. The brine shrimp bioassay was also conducted to study their in vitro cytotoxic properties which displayed potent cytotoxic activity against Vincristine. The newly synthesized compounds were all characterized through IR, 1H-NMR, and MS.
Other data
Title | Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives | Authors | Hassan M. F. Madkour ; El-Hashash, Maher Abd El-Aziz Mahmoud; Salem, Marwa Sayed; Mahmoud, Al-Shimaa Omar Ali | Keywords | Antileishmanial;Cytotoxicity;Tetrahydroquinolines;Thiadiazepino[5,6-b]quinoline;Triazino[4,3-a]quinoline;Triazolo[4,3-a]quinoline | Issue Date | 1-May-2018 | Journal | Research on Chemical Intermediates | Volume | 44 | Start page | 3349 | End page | 3364 | ISSN | 09226168 | DOI | 10.1007/s11164-018-3311-6 | Scopus ID | 2-s2.0-85045005837 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.