Straightforward synthesis of 2-chloro-N-(5-(cyanomethyl)-1,3,4-thiadiazol-2-yl)benzamide as a precursor for synthesis of novel heterocyclic compounds with insecticidal activity
Mohamed, Ali M.M.; Ismail, Mahmoud; Hassan M. F. Madkour; Aly, Aly Fahmy; Salem, Marwa S.;
Abstract
The current work is devoted to the synthesis of 2-chloro-N-(5-(cyanomethyl)-1,3,4-thiadiazol-2-yl)benzamide 5 by an efficient synthetic methodology. The authors decided to exploit the reactivity of cyanomethylene functionality to construct new heterocycles hybrid with 1,3,4-thiadiazole moiety. These compounds have been structurally characterized with the aid of elemental analysis and spectroscopic techniques such as IR, 1H and 13C NMR and mass spectra. The synthesized compounds were evaluated for the insecticidal activity against cotton leaf worm (spodoptera littoralis). Among of them, compounds 7, 10, 12 and 17 showed much higher insecticidal activity. In particular, compound 12 exhibited the highest insecticidal activity.
Other data
Title | Straightforward synthesis of 2-chloro-N-(5-(cyanomethyl)-1,3,4-thiadiazol-2-yl)benzamide as a precursor for synthesis of novel heterocyclic compounds with insecticidal activity | Authors | Mohamed, Ali M.M.; Ismail, Mahmoud ; Hassan M. F. Madkour ; Aly, Aly Fahmy; Salem, Marwa S. | Keywords | 1,3,4-thiadiazole;Aryl isothiocyanate;cyanoacetohydrazide;cyanomethylene moiety;insecticidal activity | Issue Date | 16-Nov-2020 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 50 | Issue | 22 | Start page | 3424 | End page | 3442 | ISSN | 00397911 | DOI | 10.1080/00397911.2020.1802652 | Scopus ID | 2-s2.0-85089063326 | Web of science ID | WOS:000556092700001 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.