Two smart spectrophotometric methods for the simultaneous estimation of Simvastatin and Ezetimibe in combined dosage form
Ayad, Miriam; Magdy Hanna Nassif, Nancy;
Abstract
Two simple, accurate, precise, sensitive and economic spectrophotometric methods were developed for the simultaneous determination of Simvastatin and Ezetimibe in fixed dose combination products without prior separation. The first method depends on a new chemometrics-assisted ratio spectra derivative method using moving window polynomial least square fitting method (Savitzky-Golay filters). The second method is based on a simple modification for the ratio subtraction method. The suggested methods were validated according to USP guidelines and can be applied for routine quality control testing.
Other data
Title | Two smart spectrophotometric methods for the simultaneous estimation of Simvastatin and Ezetimibe in combined dosage form | Authors | Ayad, Miriam ; Magdy Hanna Nassif, Nancy | Keywords | Ezetimibe;Spectrophotometry;Simvastatin;Savitzky-Golay | Issue Date | 25-Feb-2015 | Publisher | Elsevier | Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | Volume | 137 | Start page | 685 | End page | 691 | ISSN | 13861425 | DOI | 10.1016/j.saa.2014.08.042 | PubMed ID | 25255481 | Scopus ID | 2-s2.0-84907572528 | Web of science ID | WOS:000347269900088 |
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