DESIGN, SYNTHESIS, AND ANTIMICROBIAL EVALUATION OF NOVEL THIENOPYRIMIDINES AND TRIAZOLOTHIENOPYRIMIDINES
Mahmoud, MR; Abu El-Azm, Fatma; Ali, AT; Ali, YM;
Abstract
(Chemical Equation Presented). 2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyrimidines. The proclivity of these compounds toward one-carbon donor reagents such as carbon disulfide, phenyl isothiocyanate, and aromatic aldehydes was investigated. The structures of all synthesized compounds were ascertained by spectral and analytical data. The antimicrobial activity of the target synthesized compounds was tested against various microorganisms.
Other data
| Title | DESIGN, SYNTHESIS, AND ANTIMICROBIAL EVALUATION OF NOVEL THIENOPYRIMIDINES AND TRIAZOLOTHIENOPYRIMIDINES | Authors | Mahmoud, MR ; Abu El-Azm, Fatma ; Ali, AT; Ali, YM | Keywords | Antimicrobial activity;2-cyanoacetohydrazide;thienopyrimidines;triazolothienopyrimidines;SPECTRAL CHARACTERIZATION;DERIVATIVES;ANTAGONISTS;NITRILEN | Issue Date | 2015 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 45 | Issue | 8 | Start page | 982 | End page | 992 | ISSN | 0039-7911 | DOI | 10.1080/00397911.2014.999340 | Scopus ID | 2-s2.0-84949125291 | Web of science ID | WOS:000351232000006 |
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