Antinociceptive, anti-gastric ulcerogenic and anti-inflammatory activities of standardized egyptian pomegranate peel extract

Abstract

The utilization of the peels of the widely popular pomegranate fruit is the subject of this study. This bio waste product, which has been under study for some time as a source of potential bioactive constituents is investigated for its biological activity. A method for the extract standardization was developed using HPLC and ellagic acid as a reference standard. Results revealed that the pomegranate methanolic extract exhibited potent analgesic and anti-inflammatory activity comparable to indomethacin, used as a reference, and furthermore, caused no gastric ulcer formation.