Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

Abstract

Presently, green chemistry is a pro-active approach to pollution prevention. Additionally, enhancing the efficiency of organic synthesis, lowering the consumption of chemicals. Green Chemistry is designing chemical products and processes that reduce time, chemical, solvents, reduced hazards and obtaining heterocyclic compounds from simple starting materials which are fundamental goals in organic synthesis1-5. Grinding considered as simplest green chemistry protocol which has proven to be an efficient, economical and environmentally benign process. 1,2,4-Triazines play an essential task in various biological routes and in synthesis of drugs. Therefore, a lot of heterocyclic systems attitude 1,2,4- triazines are found to have significant pharmacological effects6-13. That targets have anti-AIDS14,15, antiviral16, anticancer17- 20, antimicrobial21-24, antitumor25, antithelmintic drugs26. The nature of substituent in 1,2,4-triazines have prompt affect on the orientation of cyclization reaction27, so that the substituted at position 6 of 3-hydrazino-5-hydroxy-1,2,4-triazine effect on the orientation of cyclization to form 1,2,4-triazolo[1,2,4]triazines. When the substituent was an electron with drawing group, 1,2,4-triazolo[3,4-c][1,2,4]triazines were created in neutral or acidic medium, while, when substituted was an electron donating group and the reagent was acidic 1,2,4-triazolo[4,3-b][1,2,4]triazines were produced.