The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome
Mahmoud, Asmaa; Faten S. Abo-Zeid; Asmaa M. Elfiky;
Abstract
Polycystic ovary syndrome (PCOS) is a multi-factorial endocrine disorder associated with hyperandrogenism.
Dehydroepiandrosterone (DHEA) administration to prepubertal rats stimulates androgen biosynthesis and generation of the PCOS model. The present study aimed to evaluate the anti-androgenic effects of quercetin (Q) in
comparison with metformin (MET) on hyperandrogenism and ovarian dysfunction in a DHEA-induced PCOS rat
model. After induction of PCOS, female rats were allocated into six groups with 7 rats in each group: normal
control; PCOS (DHEA), MET (25 mg/kg, oral administration), Q (25 mg/kg, oral administration), DHEA + MET
(25 mg/kg, oral administration), and DHEA + Q (25 mg/kg, oral administration) for 28 days. MET and Q
individually reduced body weight, serum free testosterone (T) and luteinizing hormone (LH), and LH/folliclestimulating hormone (FSH) ratio in the PCOS rats. Both treatments elevated estradiol (E2) level, ovarian aromatase protein content, and E2/free T ratio in the PCOS rats. Additionally, MET and Q increased preantral,
antral, and preovulatory follicles and corpora lutea counts, while both treatments decreased atretic follicle count
and eliminated the formation of cysts in the PCOS rats. MET and Q reduced ovarian Bax and elevated Bcl-2
protein abundance in the PCOS rats. Our study revealed that Q is as effective as MET in reducing hyperandrogenism via decreasing free T level and improving hypothalamic-pituitary-ovarian axis function. The results
suggest that MET and Q may enhance E2 concentration, ovarian aromatase protein content, folliculogenesis, and
decrease atresia via attenuation of hyperandrogenism in PCOS rats.
Dehydroepiandrosterone (DHEA) administration to prepubertal rats stimulates androgen biosynthesis and generation of the PCOS model. The present study aimed to evaluate the anti-androgenic effects of quercetin (Q) in
comparison with metformin (MET) on hyperandrogenism and ovarian dysfunction in a DHEA-induced PCOS rat
model. After induction of PCOS, female rats were allocated into six groups with 7 rats in each group: normal
control; PCOS (DHEA), MET (25 mg/kg, oral administration), Q (25 mg/kg, oral administration), DHEA + MET
(25 mg/kg, oral administration), and DHEA + Q (25 mg/kg, oral administration) for 28 days. MET and Q
individually reduced body weight, serum free testosterone (T) and luteinizing hormone (LH), and LH/folliclestimulating hormone (FSH) ratio in the PCOS rats. Both treatments elevated estradiol (E2) level, ovarian aromatase protein content, and E2/free T ratio in the PCOS rats. Additionally, MET and Q increased preantral,
antral, and preovulatory follicles and corpora lutea counts, while both treatments decreased atretic follicle count
and eliminated the formation of cysts in the PCOS rats. MET and Q reduced ovarian Bax and elevated Bcl-2
protein abundance in the PCOS rats. Our study revealed that Q is as effective as MET in reducing hyperandrogenism via decreasing free T level and improving hypothalamic-pituitary-ovarian axis function. The results
suggest that MET and Q may enhance E2 concentration, ovarian aromatase protein content, folliculogenesis, and
decrease atresia via attenuation of hyperandrogenism in PCOS rats.
Other data
Title | The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome | Authors | Mahmoud, Asmaa ; Faten S. Abo-Zeid; Asmaa M. Elfiky | Keywords | PCOS;Quercetin;Metformin;Hyperandrogenism;DHEA | Issue Date | Jan-2022 | Publisher | Elsevier | Journal | Steroids | Volume | January | Issue | 177 | Start page | 108936 | DOI | 10.1016/j.steroids.2021.108936 |
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