Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats
Shimaa El-Masry; Hanem Abdel-Sabour Ali; Nora M. El-Sheikh; Awad, Safaa;
Abstract
Nephrotoxicity is a complication due to the effect of some toxic chemicals on kidneys. Current study
planned to screen the effect of coriander and fennel aqueous seeds extracts on lead-induced nephrotoxicity.
Seventy-two adult male rats were equally divided to 6 groups: group (1) normal control, group (2) leadtoxicated
rats were received 50 mg/kg b.wt of lead acetate by gastric tube daily, groups (3-6) were leadtoxicated
and administered aqueous seeds extracts of coriander (250 and 500 mg/kg body weight/day) and
fennel (100 and 150 mg/kg body weight/day), respectively. Lead-induced renal damage was evidenced by a
significant elevation of serum and renal lead with reduction of serum delta amino levulinic acid dehydratase
activity. Renal dysfunction was diagnosed by a significant elevation of kidney function tests accompanied with
reduction in creatinine clearance. Results evidenced a significant increase of serum sodium and potassium
concentrations and their depletion in urine. Renal oxidant-antioxidant balance was disturbed which evidenced
by significant increase in renal malondialdehyde and nitric oxide and significant decrease in renal reduced
glutathione, catalase, glutathione-S-transferase and superoxide dismutase activity. Treatment with coriander
and fennel seeds extracts exerted a significant improvement of most of the biochemical parameters compared to
lead group.
planned to screen the effect of coriander and fennel aqueous seeds extracts on lead-induced nephrotoxicity.
Seventy-two adult male rats were equally divided to 6 groups: group (1) normal control, group (2) leadtoxicated
rats were received 50 mg/kg b.wt of lead acetate by gastric tube daily, groups (3-6) were leadtoxicated
and administered aqueous seeds extracts of coriander (250 and 500 mg/kg body weight/day) and
fennel (100 and 150 mg/kg body weight/day), respectively. Lead-induced renal damage was evidenced by a
significant elevation of serum and renal lead with reduction of serum delta amino levulinic acid dehydratase
activity. Renal dysfunction was diagnosed by a significant elevation of kidney function tests accompanied with
reduction in creatinine clearance. Results evidenced a significant increase of serum sodium and potassium
concentrations and their depletion in urine. Renal oxidant-antioxidant balance was disturbed which evidenced
by significant increase in renal malondialdehyde and nitric oxide and significant decrease in renal reduced
glutathione, catalase, glutathione-S-transferase and superoxide dismutase activity. Treatment with coriander
and fennel seeds extracts exerted a significant improvement of most of the biochemical parameters compared to
lead group.
Other data
Title | Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats | Authors | Shimaa El-Masry; Hanem Abdel-Sabour Ali; Nora M. El-Sheikh; Awad, Safaa | Keywords | lead;nephrotoxicity;coriander;fennel;rats | Issue Date | 16-Jun-2016 | Journal | International Journal of Research Studies in Biosciences (IJRS) | Volume | 4 | Issue | 6 | Start page | 36 | End page | 45 |
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