Reaction of 2-hydroxy-N′-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide with some phosphorus reagents. Synthesis and evaluation of anticancer activity of novel α-hydrazinophosphonic acid, 1,4,5,2λ⁵-oxadiazaphosphinines, and 1,3,2λ⁵-benzoxazaphosphinines bearing a chromone ring

Abstract

Novel 1,4,5,2-Oxadiazaphosphinines, 1,3,2-benzoxazaphosphinines, and α-hydrazinophosphonic acid bearing a chromone ring were obtained by reactions of 2-hydroxy-N′-[(4-oxo-4H-chromen-3-yl)-methylidene]benzohydrazide with some phosphorus reagents such as phosphonic acid and its esters, phosphorus sulfides, and phosphorus halides. The synthesized compounds were evaluated for their anticancer activity against four cancer cell lines. Two compounds exhibited high effects against MCF-7 breast cancer cells and on the expression of VEGF inhibition.