SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF NOVEL AZOLYL, AZINYL, PYRANYL, CHROMONYL AND AZEPINYL PHOSPHONATES
Ali, TE; Abdel-Aziz, SA; El-Edfawy, SM; Mohamed, EHA; Abdel-Kariem, S. M.;
Abstract
A facile synthetic methodology of novel azolyl, azinyl and azepinyl phosphonates as cyclic α-aminophosphonates was described. Chromonyl α-aminophosphonates, γ-pyranyl and γ-pyridinyl phosphonates were also prepared. The methodology depends on reaction of 6-methyl-3- formylchromone, nitrogen and carbon nucleophiles in the presence of diethyl phosphite in one-pot three-components under solvent-free conditions. The products were evaluated for their antimicrobial activities and antioxidant properties. © 2013 The Japan Institute of Heterocyclic Chemistry.
Other data
| Title | SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF NOVEL AZOLYL, AZINYL, PYRANYL, CHROMONYL AND AZEPINYL PHOSPHONATES | Authors | Ali, TE; Abdel-Aziz, SA; El-Edfawy, SM; Mohamed, EHA; Abdel-Kariem, S. M. | Keywords | alpha-Aminophosphonate Ester;Phosphonate Ester;Chromone;Ring Opening and Ring Closure Reactions;Antimicrobial Activity;ALPHA-AMINOPHOSPHONATE MOIETY;KABACHNIK-FIELDS REACTION;SOLVENT-FREE SYNTHESIS;AMINO-ACIDS;DERIVATIVES;INHIBITORS;HETEROCYCLES;DIPHENYL;AGENTS | Issue Date | 2013 | Publisher | PERGAMON-ELSEVIER SCIENCE LTD | Journal | Heterocycles | Volume | 87 | Issue | 12 | Start page | 2513 | End page | 2532 | ISSN | 0385-5414 | DOI | 10.3987/COM-13-12836 | Scopus ID | 2-s2.0-84889261748 | Web of science ID | WOS:000330487600004 |
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