ASSESSING THE EFFECTS OF ORLISTAT AS AN ANTI-OBESITY DRUG IN HIGH FAT DIET INDUCED OBESITY IN MALE RATS
Enas Saleh Abdel-Baky; Omnia Nasr Abdel-Rahman;
Abstract
The present work was designed to evaluate the effectiveness of the orlistat drug on some
hormones and biochemical parameters in male rats received a high fat diet (HFD). Twenty-four
rats were divided into four groups: 1st group administered normal diet, 2nd group administered
HFD, the 3rd group administered HFD plus 9.5 mg/kg b.w./day orlistat, and the 4th group
administered HFD diet plus 19 mg/kg b.w./day orlistat. The experimental period was for four
weeks. At the end of the experiment, blood samples were obtained for biochemical and
hormonal assays. The administration of HFD for four weeks increased significantly the weight
gain, serum total cholesterol (TC), triglycerides (TAG), low density lipoprotein (LDL-c),
glucose, insulin, triiodothyronine (T3), thyroxine (T4), leptin, with the significant decrease in
high density lipoprotein (HDL-c), ghrelin, thyrotropin (TSH) and testosterone hormones in the
serum as compared with the control group. The treatment with orlistat neutralized the levels of
the measured parameters as compared with HFD fed rats and the results were correlated with
the dose of orlistat. In conclusion, an improvement was observed in the biochemical and
hormonal results by the treatment with orlistat drug.
hormones and biochemical parameters in male rats received a high fat diet (HFD). Twenty-four
rats were divided into four groups: 1st group administered normal diet, 2nd group administered
HFD, the 3rd group administered HFD plus 9.5 mg/kg b.w./day orlistat, and the 4th group
administered HFD diet plus 19 mg/kg b.w./day orlistat. The experimental period was for four
weeks. At the end of the experiment, blood samples were obtained for biochemical and
hormonal assays. The administration of HFD for four weeks increased significantly the weight
gain, serum total cholesterol (TC), triglycerides (TAG), low density lipoprotein (LDL-c),
glucose, insulin, triiodothyronine (T3), thyroxine (T4), leptin, with the significant decrease in
high density lipoprotein (HDL-c), ghrelin, thyrotropin (TSH) and testosterone hormones in the
serum as compared with the control group. The treatment with orlistat neutralized the levels of
the measured parameters as compared with HFD fed rats and the results were correlated with
the dose of orlistat. In conclusion, an improvement was observed in the biochemical and
hormonal results by the treatment with orlistat drug.
Other data
Title | ASSESSING THE EFFECTS OF ORLISTAT AS AN ANTI-OBESITY DRUG IN HIGH FAT DIET INDUCED OBESITY IN MALE RATS | Authors | Enas Saleh Abdel-Baky ; Omnia Nasr Abdel-Rahman | Issue Date | 2021 | Publisher | Faculty of Pharmacy, Assiut University | Journal | Bulletin of Pharmaceutical Sciences | Volume | 44 | Issue | 1 | Start page | 131 | End page | 138 | DOI | 10.21608/BFSA.2021.174138 |
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