Effects of Copper Sulphate Supplementation on Some Physiological Parameters in Male Albino Rats
Enas S. Abdel-Baky;
Abstract
Copper is an essential trace element required for different
metabolic functions. The aim was to investigate the toxic effects
induced by the over-exposure to copper sulphate. Materials and
Methods: Rats were divided into three groups, as follows: the
first group (GI) served as untreated control. The second group
(GII) and the third group (GIII) were orally treated with a daily
dose of copper sulphate 100 mg/kg b.wt. And 200 mg/kg b.wt.,
respectively for two weeks. Results: At the end of the
experiment, blood samples were collected and the sera were
separated for estimation the levels of total testosterone, follicule
stimulating hormone (FSH), leutilizing hormone (LH) and
prolactin hormone, alanine amino transferase (ALT), aspartate
amino transferase (AST) and alkaline phosphatase (ALP)
enzymes; urea, uric acid and creatinine. Results showed a
marked reduction in the total testosterone, FSH, LH, and
prolactin levels in all treated groups compared to the
corresponding controls. Whereas, serum activities ALT, AST,
and ALP enzymes and the urea, uric acid and creatinine levels
were obviously elevated in all treated groups comparing with
control group. Conclusion: The present results revealed that
copper sulphate caused disruption in the sexual hormones and all
biochemical parameters measured in the current study.
metabolic functions. The aim was to investigate the toxic effects
induced by the over-exposure to copper sulphate. Materials and
Methods: Rats were divided into three groups, as follows: the
first group (GI) served as untreated control. The second group
(GII) and the third group (GIII) were orally treated with a daily
dose of copper sulphate 100 mg/kg b.wt. And 200 mg/kg b.wt.,
respectively for two weeks. Results: At the end of the
experiment, blood samples were collected and the sera were
separated for estimation the levels of total testosterone, follicule
stimulating hormone (FSH), leutilizing hormone (LH) and
prolactin hormone, alanine amino transferase (ALT), aspartate
amino transferase (AST) and alkaline phosphatase (ALP)
enzymes; urea, uric acid and creatinine. Results showed a
marked reduction in the total testosterone, FSH, LH, and
prolactin levels in all treated groups compared to the
corresponding controls. Whereas, serum activities ALT, AST,
and ALP enzymes and the urea, uric acid and creatinine levels
were obviously elevated in all treated groups comparing with
control group. Conclusion: The present results revealed that
copper sulphate caused disruption in the sexual hormones and all
biochemical parameters measured in the current study.
Other data
Title | Effects of Copper Sulphate Supplementation on Some Physiological Parameters in Male Albino Rats | Authors | Enas S. Abdel-Baky | Keywords | Biochemical parameters;Copper sulphate;Sexual hormones | Issue Date | 2019 | Publisher | Egyptian Society of Biological Sciences | Journal | Egyptian Academic Journal of Biological Sciences, B. Zoology | Volume | 11 | Issue | 2 | Start page | 137 | End page | 145 |
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