Effect of Psidium guajava leaf extract, glibenclamide and their combination on rat model of diabetes induced by streptozotocin
Omnia Nasr Abdelrhman Mohamed; Yasser A. Khadrawy; Gamal Abdel-Aty Hafez; Shadia Ali Radwan;
Abstract
Aim: The present aim is to evaluate the anti-diabetic effect of aqueous extract of guava (Psidium guajava) leaf
using rat model of diabetes induced by streptozotocin. In addition, the effect of this extract on liver and kidney
functions induced in rat model of diabetes were investigated.
Material and Methods: Rats were divided randomly into: control group, rat model of diabetes induced by
streptozotocin, rat model of diabetes treated with aqueous extract of guava leaf, rat model of diabetes treated
with glibenclamide and rat model of diabetes treated with aqueous extract of guava leaf plus glibenclamide.
Result: In the present rat model of diabetes a significant decrease in the serum insulin level and a significant
increase in glucose level were detected. Streptozotocin induced a significant increase in the activities of AST,
ALT, ALP and a significant increase in the levels of bilirubin, urea, creatinine and uric acid. In addition
histopathological and immunological changes were detected in the pancreatic tissue. The present data revealed
that aqueous extract of guava leaf improved the reduced insulin level and the high glucose level induced by
streptozotocin. This was associated with an improvement in the changes in the liver and kidney functions. Loss
of body weight gain induced by streptozotocin was alleviated by guava leaf extract, glibenclamide or both.
Conclusion: According to the present findings it could be concluded that the aqueous extract of guava leaf has
a potent anti-hyperglycemic effect on rat model of diabetes induced by streptozotocin with hepatic and renal
protective effects
using rat model of diabetes induced by streptozotocin. In addition, the effect of this extract on liver and kidney
functions induced in rat model of diabetes were investigated.
Material and Methods: Rats were divided randomly into: control group, rat model of diabetes induced by
streptozotocin, rat model of diabetes treated with aqueous extract of guava leaf, rat model of diabetes treated
with glibenclamide and rat model of diabetes treated with aqueous extract of guava leaf plus glibenclamide.
Result: In the present rat model of diabetes a significant decrease in the serum insulin level and a significant
increase in glucose level were detected. Streptozotocin induced a significant increase in the activities of AST,
ALT, ALP and a significant increase in the levels of bilirubin, urea, creatinine and uric acid. In addition
histopathological and immunological changes were detected in the pancreatic tissue. The present data revealed
that aqueous extract of guava leaf improved the reduced insulin level and the high glucose level induced by
streptozotocin. This was associated with an improvement in the changes in the liver and kidney functions. Loss
of body weight gain induced by streptozotocin was alleviated by guava leaf extract, glibenclamide or both.
Conclusion: According to the present findings it could be concluded that the aqueous extract of guava leaf has
a potent anti-hyperglycemic effect on rat model of diabetes induced by streptozotocin with hepatic and renal
protective effects
Other data
Title | Effect of Psidium guajava leaf extract, glibenclamide and their combination on rat model of diabetes induced by streptozotocin | Authors | Omnia Nasr Abdelrhman Mohamed ; Yasser A. Khadrawy; Gamal Abdel-Aty Hafez; Shadia Ali Radwan | Keywords | Rats;Hypoglycemic;Streptozotocin;Psidium guajava;liver functions;kidney functions | Issue Date | 18-Jul-2018 | Journal | The Egyptian Journal of Hospital Medicine | Volume | 72 | Issue | 6 |
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