Convenient Methodology for Some Heterocyclization Reactions with Thioxopyrimidine Derivatives
K. M. El-Mahdy; Farouk, Osama;
Abstract
A simple and effi cient method for derivatization of the pyrimidine nucleus is developed. The readily
available 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one has been used as a versatile building block for the
synthesis of thioxopyrimidine derivatives. A variety of novel fused pyrimidines has been prepared via nucleophilic
and/or electrophilic reactions of thioxopyrimidine derivatives. The structures of the newly synthesized products
have been deduced on the basis of elemental analysis and spectral data.
available 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one has been used as a versatile building block for the
synthesis of thioxopyrimidine derivatives. A variety of novel fused pyrimidines has been prepared via nucleophilic
and/or electrophilic reactions of thioxopyrimidine derivatives. The structures of the newly synthesized products
have been deduced on the basis of elemental analysis and spectral data.
Other data
| Title | Convenient Methodology for Some Heterocyclization Reactions with Thioxopyrimidine Derivatives | Authors | K. M. El-Mahdy; Farouk, Osama | Keywords | condensation reactions, Michael addition, pyridopyrimidine, Mannich reaction, thiadiazine, electrophilic reactions | Issue Date | Nov-2020 | Volume | 56 | Issue | 11 | Start page | 2022 | End page | 2027 |
Attached Files
| File | Description | Size | Format | Existing users please Login |
|---|---|---|---|---|
| Paper No. 2.pdf | 616 kB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.