Synthetic approaches for nitrogen bridgehead pyrido-[1,2-b][1,2,4]triazepines and annulated compounds using 4-(8-allylchromon-3-yl)-1,6-diamino-2-oxo-1,2-dihydro-pyridine-3,5-dicarbonitrile
Magdy A. Ibrahim;
Abstract
– Some new nitrogen bridgehead pyrido[1,2-b][1,2,4]triazepines linked 8-allylchromone moiety have been synthesized from reaction of novel 4-(8-allyl-chromon-3-yl)-1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (3) with a variety of α,γ-bifunctional electrophiles including dibenzoylmethane, ethyl benzoylacetate, 3-[bis(methylthio)methylidene]pentane-2,4-dione, 2-cyano-3,3-bis(methylthio)acrylonitrile, 2-cyano-3,3-bis(methylthio)prop-2-enamide, 5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde, 2-chloro-3-formyl-quinoline, (p-methoxybenzylidene)malononitrile and ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate. Some novel pyrazolo[3,4-e]pyrido[1,2-b]-[1,2,4]triazepines were also synthesized. Structures of the newly synthesized products have been deduced upon the help of elemental analysis and spectral data (IR, 1H NMR, 13NMR, mass spectra).
Other data
Title | Synthetic approaches for nitrogen bridgehead pyrido-[1,2-b][1,2,4]triazepines and annulated compounds using 4-(8-allylchromon-3-yl)-1,6-diamino-2-oxo-1,2-dihydro-pyridine-3,5-dicarbonitrile | Authors | Magdy A. Ibrahim | Issue Date | 1-Jan-2021 | Journal | Heterocycles | ISSN | 03855414 | DOI | 10.3987/COM-21-14487 | Scopus ID | 2-s2.0-85108879333 |
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