Synthesis and reactivity of enaminone of naphtho[b]1,4-oxazine: One pot synthesis of novel isolated and heterocycle-fused derivatives with antimicrobial and antifungal activities

Abstract

Abstract The synthesis of the multifunctional, hitherto unreported 3-(3-(dimethylamino)acryloyl)-2H-naphtho[1,2-b][1,4]oxazin-2-one was described and its utility as a versatile building block was demonstrated for the synthesis of some new pyrimidines, pyrazoles, isoxazoles, pyrazolo[a]pyrimidines, triazolo[a]pyrimidines, pyrido[d]pyrimidines, pyrido[d]pyrimidines, piperidines, pyrido[a]benzimidazoles, 2H-pyran-3carboxamides, benzofurans, naphtho[b]furans and pyrazolo[c][1, 2, 4]triazines of potential biological activities. The synthesized compounds were characterized by IR, ¹H NMR, ¹³C NHR and mass spectral data. Some of the compounds were evaluated for antimicrobial activities.