Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment in rats by modulating beta-catenin
El-Asfar, Rana K; El-Derany, Marwa O; Sallam, Al-Aliaa M; Wahdan, Sara; El-Demerdash, Ebtehal; Sayed, Sayed A; El-Mesallamy, Hala O;
Abstract
Tamoxifen (TAM) therapy has been associated with fatty liver diseases. Recently, multiple reports have also shown that TAM is related to cognitive impairment in patients with breast cancer. Luteolin, a natural flavonoid, has been traditionally used to treat various inflammatory disorders, such as chronic liver diseases, cognitive impairments, and cancers. This study aimed to evaluate the potential protective effects of luteolin against the cognitive defects and liver steatosis induced by TAM in rats.
Other data
| Title | Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment in rats by modulating beta-catenin | Authors | El-Asfar, Rana K; El-Derany, Marwa O; Sallam, Al-Aliaa M; Wahdan, Sara ; El-Demerdash, Ebtehal; Sayed, Sayed A; El-Mesallamy, Hala O | Keywords | Cognitive impairment;Fatty liver;Inflammation;Luteolin;Tamoxifen;β-catenin | Issue Date | 5-Oct-2021 | Publisher | ELSEVIER | Journal | European journal of pharmacology | ISSN | 0014-2999 | DOI | 10.1016/j.ejphar.2021.174337 | PubMed ID | 34265292 | Scopus ID | 2-s2.0-85110478884 | Web of science ID | WOS:000688580900002 |
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