Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats
Shaker, Fatma H; El-Derany, Marwa O; Sara Abdel Moneim Wahdan; El-Demerdash, Ebtehal; El-Mesallamy, Hala O;
Abstract
Cognitive decline is one of the most challenging issues for cancer survivors undergoing doxorubicin (DOX) based chemotherapy. Oxidative stress and inflammation primarily through tumor necrosis factor-alpha (TNF-α) are considered the key contributors to DOX-induced chemobrain. Berberine (BBR) has attracted much interest because of its anti-oxidative, anti-inflammatory and anti-apoptotic actions. This study aimed to evaluate the potential neuroprotective effect of BBR in DOX-induced neurodegeneration and cognitive deficits.
Other data
| Title | Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats | Authors | Shaker, Fatma H; El-Derany, Marwa O; Sara Abdel Moneim Wahdan ; El-Demerdash, Ebtehal; El-Mesallamy, Hala O | Keywords | Apoptosis; Berberine; Chemobrain; Inflammation; Oxidative stress | Issue Date | 15-Mar-2021 | Publisher | PERGAMON-ELSEVIER SCIENCE LTD | Journal | Life Sciences | Volume | 269 | ISSN | 0024-3205 | DOI | 10.1016/j.lfs.2021.119078 | PubMed ID | 33460662 | Scopus ID | 2-s2.0-85099840003 | Web of science ID | WOS:000616196300042 |
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