Cytotoxic effects of 2-methoxyestradiol in the hepatocellular carcinoma cell line HepG2

El-Naga, Reem N.; El-Demerdash, Ebtehal; Youssef, Samar S; Abdel-Naim, Ashraf B; El-Merzabani, Mahmoud;

Abstract


The study was designed to examine the potential cytotoxicity of 2-methoxyestradiol (2ME2), a natural 17beta-estradiol metabolite, in hepatocellular carcinoma and the possible underlying mechanisms for this cytotoxicity.


Other data

Title Cytotoxic effects of 2-methoxyestradiol in the hepatocellular carcinoma cell line HepG2
Authors El-Naga, Reem N. ; El-Demerdash, Ebtehal; Youssef, Samar S; Abdel-Naim, Ashraf B; El-Merzabani, Mahmoud
Keywords APOPTOSIS;2-Methoxyestradiol;Hepatocellular carcinoma;Apoptosis;MULTIDRUG-RESISTANCE;GROWTH-FACTOR;Angiogenesis;TUMOR-GROWTH;ALPHA;ARREST;INDUCTION;ANGIOGENESIS
Issue Date 2009
Publisher KARGER
Journal Pharmacology 
ISSN 0031-7012
DOI 10.1159/000221062
PubMed ID 19478548
Scopus ID 2-s2.0-66149089173
Web of science ID WOS:000267841000002

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Citations 6 in pubmed
Citations 15 in scopus


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