Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals
El-Naga, Reem N.; Azab, Samar S; El-Demerdash, Ebtehal; Shaarawy, Sabry; El-Merzabani, Mahmoud; Ammar, el-Sayed M;
Abstract
The present study investigated and compared the potential chemosensitizing effect of indole-3-carbinol (I3C) and epigallocatechin-3-gallate (EGCG) on TRAIL-induced apoptosis in human hepatocellular carcinoma (HCC) HepG2 cells as well as the possible mechanisms underlying these modulatory effects, particularly their effects on TRAIL death receptors (DR), Bcl-2 and c-FLIP proteins expression.
Other data
| Title | Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals | Authors | El-Naga, Reem N. ; Azab, Samar S; El-Demerdash, Ebtehal; Shaarawy, Sabry; El-Merzabani, Mahmoud; Ammar, el-Sayed M | Keywords | DEATH;TRAIL;Indole-3-carbinol;Epigallocatechin-3-gallate;Hepatocellular carcinoma;c-FLIP;Death receptors;GREEN TEA POLYPHENOL;HUMAN HEPATOMA-CELLS;MEDIATED APOPTOSIS;DNA FRAGMENTATION;DOWN-REGULATION;UP-REGULATION; BCL-2 FAMILY;CANCER-CELLS;INDOLE-3-CARBINOL | Issue Date | 21-Mar-2013 | Publisher | PERGAMON-ELSEVIER SCIENCE LTD | Journal | Life Sciences | ISSN | 0024-3205 | DOI | 10.1016/j.lfs.2013.01.017 | PubMed ID | 23352978 | Scopus ID | 2-s2.0-84875444019 | Web of science ID | WOS:000316527600005 |
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