The impact of active vitamin D administration on the clinical outcomes of acne vulgaris
El Borolossy, Radwa;
Abstract
Acne vulgaris is one of the most common chronic inflammatory skin disorder affecting millions of
people worldwide. Vitamin D deficiency has a role in various inflammatory skin diseases as acne. This
study aimed to investigate the serum level of 25 hydroxy vitamin D in acne patients and to assess
the efficacy and safety of active vitamin D in management of acne. This study was conducted on 100
patients with acne and 100 healthy controls, then the 100 acne patients were randomized to either
the study group that received 0.25ug alfacalcidol daily or the placebo group that received oral placebo
during the 3months study period. Serum levels of 25-hydroxy-vitamin D were significantly lower
in acne patients than in healthy control and were inversely correlated to the severity of acne. After
alfacalcidol administration, the study group showed significant higher level of 25(OH) D levels
(p<.05) compared to placebo group. In addition, median serum level of IL6 and TNFa significantly
decreased (p<.05) in the study group in comparison to placebo group and as compared to their
baseline results. Acne patients are more commonly to have vitamin D deficiency as compared to
healthy people and hence, alfacalcidol might have a beneficial role in the acne management with no
reported side effects.
people worldwide. Vitamin D deficiency has a role in various inflammatory skin diseases as acne. This
study aimed to investigate the serum level of 25 hydroxy vitamin D in acne patients and to assess
the efficacy and safety of active vitamin D in management of acne. This study was conducted on 100
patients with acne and 100 healthy controls, then the 100 acne patients were randomized to either
the study group that received 0.25ug alfacalcidol daily or the placebo group that received oral placebo
during the 3months study period. Serum levels of 25-hydroxy-vitamin D were significantly lower
in acne patients than in healthy control and were inversely correlated to the severity of acne. After
alfacalcidol administration, the study group showed significant higher level of 25(OH) D levels
(p<.05) compared to placebo group. In addition, median serum level of IL6 and TNFa significantly
decreased (p<.05) in the study group in comparison to placebo group and as compared to their
baseline results. Acne patients are more commonly to have vitamin D deficiency as compared to
healthy people and hence, alfacalcidol might have a beneficial role in the acne management with no
reported side effects.
Other data
Title | The impact of active vitamin D administration on the clinical outcomes of acne vulgaris | Authors | El Borolossy, Radwa | Issue Date | 3-Jan-2020 | Journal | Journal of dermatological treatment | Volume | 32 | Issue | 7 | Start page | 756 | End page | 761 | DOI | https://doi.org/10.1080/09546634.2019.1708852 |
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