Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients
El Borolossy, Radwa;
Abstract
Background: Chronic spontaneous urticaria (CSU) is a common skin disorder affecting negatively
patients’ lives. Vitamin D deficiency has been reported to be associated to many allergic
skin disorders.
Objective: This study aimed to evaluate the association between the serum level of 25 hydroxy vitamin
D and CSU and to assess the efficacy and safety of active vitamin D in management of CSU.
Methods: The study was conducted on 77 patients with CSU and 67 healthy controls, then the 77
CSU patients were randomized to either the study group that received 0.25 mg alfacalcidol daily or
the placebo group that received oral placebo for 12 weeks.
Results: Serum 25(OH) D was significantly lower in CSU as compared to healthy controls and was
negatively correlated to the urticarial severity. After alfacalcidol administration, the study group
showed significant higher level of 25(OH) D compared to the placebo group. In addition, the mean
serum level of IL6, hsCRP and TNFa significantly decreased in the study group in comparison to the
placebo group and as compared to their baseline results.
Conclusion: Vitamin D deficiency is more common in CSU patients as compared to healthy people
and hence, alfacalcidol might have a beneficial role as add on therapy in CSU management with no
reported side effects.
patients’ lives. Vitamin D deficiency has been reported to be associated to many allergic
skin disorders.
Objective: This study aimed to evaluate the association between the serum level of 25 hydroxy vitamin
D and CSU and to assess the efficacy and safety of active vitamin D in management of CSU.
Methods: The study was conducted on 77 patients with CSU and 67 healthy controls, then the 77
CSU patients were randomized to either the study group that received 0.25 mg alfacalcidol daily or
the placebo group that received oral placebo for 12 weeks.
Results: Serum 25(OH) D was significantly lower in CSU as compared to healthy controls and was
negatively correlated to the urticarial severity. After alfacalcidol administration, the study group
showed significant higher level of 25(OH) D compared to the placebo group. In addition, the mean
serum level of IL6, hsCRP and TNFa significantly decreased in the study group in comparison to the
placebo group and as compared to their baseline results.
Conclusion: Vitamin D deficiency is more common in CSU patients as compared to healthy people
and hence, alfacalcidol might have a beneficial role as add on therapy in CSU management with no
reported side effects.
Other data
Title | Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients | Authors | El Borolossy, Radwa | Keywords | Chronic spontaneous urticaria; active vitamin D; interleukin 6; tumor necrosis factor alpha | Issue Date | 13-May-2020 | Publisher | Taylor and Francis | Journal | Journal of dermatological treatment | Volume | 33 | Issue | 1 | Start page | 427 | End page | 432 |
Attached Files
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2- Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients.pdf | 1.05 MB | Adobe PDF | Request a copy |
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