The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial
El Borolossy, Radwa;
Abstract
BACKGROUND AND AIM: Vascular calcification is one of the most prevalent disorders in pediatric hemodialysis patients that
eventually lead to cardiovascular morbidity. Vitamin K2 was investigated in adults in previous studies and showed favorable effects
on calcification markers. Our aim in this study was to evaluate the efficacy and safety of vitamin K2 and cholecalciferol on the
calcification regulators in pediatric patients.
METHODS: A prospective, randomized and controlled trial was conducted on sixty hemodialysis pediatric patients who were
divided to four groups; Group 1: administered 100 μg of vitamin K2 (MK-7); Group 2: administered 10 μg of native vitamin D; Group
3: administered 100 μg of vitamin K2 (MK-7) in addition 10 μg of native vitamin D, and Group 4: administered the standard therapy
only. The duration of supplementation was 4 months. In addition to a group of healthy normal control of age and sex-matched.
RESULTS: At the end of the study period, serum levels of FGF23, dp-uc-MGP, and uc-OC were measured. It was found that serum
levels of dp-uc-MGP, uc-OC, and FGF23 were significantly higher (p < 0.05) in the hemodialysis patients as compared to the healthy
normal control. After 4 months, group 3 revealed the most significant decrease in dp-uc-MGP, uc-OC as compared to the other
groups. However, there was no change in FGF23.
CONCLUSION: Vitamin K2 and native vitamin D showed a beneficial effect on calcification regulators in pediatric hemodialysis
patients.
eventually lead to cardiovascular morbidity. Vitamin K2 was investigated in adults in previous studies and showed favorable effects
on calcification markers. Our aim in this study was to evaluate the efficacy and safety of vitamin K2 and cholecalciferol on the
calcification regulators in pediatric patients.
METHODS: A prospective, randomized and controlled trial was conducted on sixty hemodialysis pediatric patients who were
divided to four groups; Group 1: administered 100 μg of vitamin K2 (MK-7); Group 2: administered 10 μg of native vitamin D; Group
3: administered 100 μg of vitamin K2 (MK-7) in addition 10 μg of native vitamin D, and Group 4: administered the standard therapy
only. The duration of supplementation was 4 months. In addition to a group of healthy normal control of age and sex-matched.
RESULTS: At the end of the study period, serum levels of FGF23, dp-uc-MGP, and uc-OC were measured. It was found that serum
levels of dp-uc-MGP, uc-OC, and FGF23 were significantly higher (p < 0.05) in the hemodialysis patients as compared to the healthy
normal control. After 4 months, group 3 revealed the most significant decrease in dp-uc-MGP, uc-OC as compared to the other
groups. However, there was no change in FGF23.
CONCLUSION: Vitamin K2 and native vitamin D showed a beneficial effect on calcification regulators in pediatric hemodialysis
patients.
Other data
Title | The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial | Authors | El Borolossy, Radwa | Issue Date | 29-Nov-2021 | Publisher | Springer nature | Journal | European journal of clinical nutrition | Volume | 76 | Issue | 6 | Start page | 848 | End page | 854 |
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