Comparative effects of different cosurfactants on sterile prednisolone acetate ocular submicron emulsions stability and release
Ibrahim, Shaimaa; Awad, Gehanne A.S.; Geneidi, Ahmed; Mortada, Nahed D.;
Abstract
Pluronic F68 is a nonionic, thermogelling block copolymer showing a high dehydration resistance during autoclaving due to its high cloud point (>100 °C). Tween 80 (with cloud point of 72.5 °C), is a polyoxyethylene-based cosurfactant, susceptible to temperature because of a decrease in its solubility by temperature increase. This study was done to explore whether or not, when compared with Tween 80, Pluronic F68 could be used blindly as a suitable cosurfactant for the preparation of terminally sterilized ocular submicron emulsions containing a lipid soluble drug, prednisolone acetate (PA). Various oils of variable viscosities were also tried. The results proved that no prediction can be made based on previously known physico-chemical properties alone and that emulsion stability depends on the contribution of the various emulsion components including: oil, surfactant and cosurfactant, in addition to the drug properties. © 2008 Elsevier B.V. All rights reserved.
Other data
Title | Comparative effects of different cosurfactants on sterile prednisolone acetate ocular submicron emulsions stability and release | Authors | Ibrahim, Shaimaa ; Awad, Gehanne A.S.; Geneidi, Ahmed; Mortada, Nahed D. | Keywords | Interfacial film;Molecular packing;Ocular;Pluronic F68;Submicron emulsion | Issue Date | 1-Mar-2009 | Publisher | ELSEVIER SCIENCE BV | Journal | Colloids and surfaces. B, Biointerfaces | Volume | 69 | Issue | 2 | Start page | 225 | End page | 231 | ISSN | 09277765 | DOI | 10.1016/j.colsurfb.2008.11.034 | PubMed ID | 19157802 | Scopus ID | 2-s2.0-60449094959 | Web of science ID | WOS:000264463600011 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.