Antipyretic, antinociceptive and anti-inflammatory activities of certain γ-oxobutanoic acid derivatives
Abouzid, Khaled; Youssef, Khairia M.; Ahmed, Amany A.E.; Al-Zuhair, Hanaa Hussain;
Abstract
Three chemical entities were synthesized as analogs of fenbufen as well as open ring analog of suldinac and celecoxib. The new compounds were evaluated for antipyretic, antinociceptive and anti-inflammatory activities. Among these compounds, 6-benzo[1,3]dioxol-5-yl-4-oxo-hex-5-enoic acid (3) was the most active one. © Birkhäuser Boston 2005.
Other data
| Title | Antipyretic, antinociceptive and anti-inflammatory activities of certain γ-oxobutanoic acid derivatives | Authors | Abouzid, Khaled ; Youssef, Khairia M.; Ahmed, Amany A.E.; Al-Zuhair, Hanaa Hussain | Keywords | Synthesis, fenbufen | Issue Date | 31-Oct-2005 | Journal | Medicinal Chemistry Research | Start page | 26 | End page | 39 | ISSN | 10542523 | DOI | 10.1007/s00044-004-0123-6 | Scopus ID | 2-s2.0-27144510106 |
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