4-Substitutedphthalazines and phthalazinones: synthesis, characterization and beta-adrenergic blocking activity
Abouzid, Khaled; Khalil, NA; Ahmed, E.M.;
Abstract
Novel 4-(4-bromophenyl)phthalazine and phthalazinone derivatives connected through 2-propanol spacer to N-substituted piperazine residue were synthesized. All the new compounds were screened for their effect on β-adrenergic blocking activity on the norepinephrine-induced precontracted aortic ring module. Most test compounds displayed appreciable β-adrenolytic activity compared to propranolol as a reference standard. The results have shown that compounds 3a, 3d, 3e and 7c displayed appreciable inhibition of norepinephrine-induced aortic ring contraction. Graphical Abstract: A novel 4-(4-bromophenyl)phthalazine and phthalazinone derivatives connected through 2-propanol spacer to N-substituted piperazine residue were synthesized. All new compounds were screened for their effect on β-adrenergic blocking activity on the norepinephrine-induced precontracted aortic ring module.[Figure not available: see fulltext.] © 2012 Springer Science+Business Media, LLC.
Other data
Title | 4-Substitutedphthalazines and phthalazinones: synthesis, characterization and beta-adrenergic blocking activity | Authors | Abouzid, Khaled ; Khalil, NA; Ahmed, E.M. | Keywords | Phthalazines;Phthalazinones;Adrenergic beta-blockers;Arylpiperazine;DERIVATIVES;AGENTS;PYRIDAZINONE;BLOCKERS;RECEPTOR;DISEASE | Issue Date | 2013 | Publisher | SPRINGER BIRKHAUSER | Journal | Medicinal Chemistry Research | Volume | 22 | Start page | 1057 | End page | 1064 | ISSN | 1054-2523 | DOI | 10.1007/s00044-012-0099-6 | Scopus ID | 2-s2.0-84874109627 | Web of science ID | WOS:000314283500004 |
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