Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics
El-Labbad, Eman M; Ji, Xingyue; Abouzid, Khaled; Wang, Binghe;
Abstract
SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition, SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO2 prodrug design. The remaining challenges and issues will also be discussed.
Other data
| Title | Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics | Authors | El-Labbad, Eman M; Ji, Xingyue; Abouzid, Khaled ; Wang, Binghe | Keywords | Click and release;Sulfur dioxide;Prodrugs;Gasotransmitter;Drug delivery;Donors | Issue Date | 2021 | Publisher | BENTHAM SCIENCE PUBL LTD | Journal | Current topics in medicinal chemistry | Volume | 21 | Issue | 32 | Start page | 2870 | End page | 2881 | ISSN | 1568-0266 | DOI | 10.2174/1568026621666211116091354 | PubMed ID | 34784869 | Scopus ID | 2-s2.0-85122295941 | Web of science ID | WOS:000732809100004 |
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