Synthesis and antiinflammatory activity of novel indazolones
Khaled A M Abouzid; el-Abhar, H S;
Abstract
In this study, a series of new N2 substituted 1,2-dihydro-3H-indazol-3-ones (3a-d) as well as their condensed pyrazolo, pyridazino derivatives such as pyridazino[1,2-a]indazole-6,9,11-triones (4a-h) and 3,9-dioxo-3H,9H-pyrazolo[1,2-a]indazole (7) were synthesized. The antiinflammatory activity of some synthesized compounds was determined by carrageenan-induced rat paw edema technique using diclofenac as reference drug. The pharmacological data showed that most of the tested compounds exhibited a significant long lasting antiinflammatory activity, which in the case of compound 3b was superior to that of diclofenac.
Other data
| Title | Synthesis and antiinflammatory activity of novel indazolones | Authors | Khaled A M Abouzid ; el-Abhar, H S | Keywords | 3,9-dioxo-3H,9H-pyrazolo[1,2-a] indazole;Antiinflammatory activity;Pyridazino[1,2-a]indazole-6,9,11-triones | Issue Date | Jan-2003 | Journal | Archives of pharmacal research | Volume | 26 | Start page | 1 | End page | 8 | ISSN | 0253-6269 | DOI | 10.1007/BF03179922 | PubMed ID | 12568349 | Scopus ID | 2-s2.0-0042309658 |
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