3-[(6-Arylamino)pyridazinylamino]benzoic acids: design, synthesis and in vitro evaluation of anticancer activity
Khaled A M Abouzid; Khalil, Nadia A; Ahmed, Eman M; Mohamed, Khaled Omar;
Abstract
A series of novel substituted 3,6-disubstituted pyridazines based on the structure of vatalanib (PTK787) were designed and synthesized. The cytotoxicity of the final compounds was tested in vitro on HT-29 colon cancer cell line. Compounds 2a and 2b with 4-chlorophenylamino moiety, exerted the highest cytotoxic activity with IC(50) values equal to 15.3 and 3.9 μM respectively. The most promising compound, 2b, was found to be about fivefold more active than vatalanib against HT-29 colon cancer cell line.
Other data
| Title | 3-[(6-Arylamino)pyridazinylamino]benzoic acids: design, synthesis and in vitro evaluation of anticancer activity | Authors | Khaled A M Abouzid ; Khalil, Nadia A; Ahmed, Eman M; Mohamed, Khaled Omar | Keywords | Pyridazine;Colon cancer;Vatalanib;cytotoxicity;ENDOTHELIAL GROWTH-FACTOR;PYRIDAZINE DERIVATIVES;ANGIOGENESIS;INHIBITORS;RECEPTORS | Issue Date | Jan-2013 | Publisher | PHARMACEUTICAL SOC KOREA | Journal | Archives of pharmacal research | Volume | 36 | Start page | 41 | End page | 50 | ISSN | 0253-6269 | DOI | 10.1007/s12272-013-0007-8 | PubMed ID | 23307426 | Scopus ID | 2-s2.0-84873702831 | Web of science ID | WOS:000314719600004 |
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