Hepatoprotective Effect of Spirulina platensis on Liver Functions of Diabetic Rats via TNF-α and IL-6 Pathway

Abstract

Spirulina platensis (SP) microalgae is a filamentous cyanobacterium with strong dietary anti-inflammatory and Phyto-antioxidant. This study aimed to investigate the potential hepatoprotective and antioxidants effect of phenolic compounds extracted from Spirulina platensis (SPP) in Albino diabetic rats. Materials and Methods: Thirty rats were randomly divided into five groups. The first group were received normal saline. The second group were received only STZ. The third group were received (STZ) and glibenclamide (600 μg kg–1 b.wt.). The fourth group received STZ and silymarin (100 mg kg–1 b.wt.). The fifth group were treated with (STZ) following administration with (SPP) at (50 mg kg–1 b.wt.). The blood samples were collected for estimation of the liver biomarkers and the hepatic tissues were isolated for assessment of the oxidative stress markers. The TNF-α and IL-6 were also evaluated and the histopathological were studied. Results: The results show that the predominant compounds of (SPP) were pyrogallol, E-vanillic, Ellagic, catechol and Benzoic (638.5, 31.53, 19.83, 7. 62 and 6.82 mg/100 g, respectively). The animal treatments with (STZ) lead to an increase in ALT, AST and lipid peroxidation. It significantly inhibits the activities of GPx, CAT and SOD. As well as, TNF-α and IL-6 were increased. Conclusion: The results conclude that SPP may be acting as a therapeutic protective agent against liver damage in diabetic rats.