New thiophene derivative augments the antitumor activity of γ-irradiation against colorectal cancer in mice via anti-inflammatory and pro-apoptotic pathways
ElBakary, Nermeen M; Hagag, Sanaa A; Ismail, Mohamed A; El-Sayed, Wael;
Abstract
Colorectal cancer (CRC) is one of the most common types of cancer worldwide and the second cause of cancer-related deaths. It usually starts as an inflammation that progresses to adenocarcinoma. The goal of the present study was to investigate the antitumor efficacy of a new thiophene derivative against CRC in mice and explore the possible associated molecular pathways. The potential of this thiophene derivative to sensitize the CRC tumor tissue to a low dose of gamma irradiation was also investigated.
Other data
| Title | New thiophene derivative augments the antitumor activity of γ-irradiation against colorectal cancer in mice via anti-inflammatory and pro-apoptotic pathways | Authors | ElBakary, Nermeen M; Hagag, Sanaa A; Ismail, Mohamed A ; El-Sayed, Wael | Keywords | Apoptosis;COX2;Oncogene;PPARγ;iNOS;p53 | Issue Date | 3-Nov-2022 | Publisher | SPRINGER | Journal | Discover Oncology | Volume | 13 | ISSN | 1868-8497 | DOI | 10.1007/s12672-022-00583-1 | PubMed ID | 36326938 | Scopus ID | 2-s2.0-85141102270 | Web of science ID | WOS:000878659000001 |
Attached Files
| File | Description | Size | Format | Existing users please Login |
|---|---|---|---|---|
| discover oncology nermeen.pdf | 2.21 MB | Adobe PDF | Request a copy |
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