Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway
George, Mina Y.; El-Derany, Marwa O; Ahmed, Yasmine; Zaher, Malvina; Ibrahim, Caroline; Waleed, Habiba; Khaled, Hajar; Khaled, Gehad; Saleh, Ahmed; Alshafei, Huda; Alshafei, Rahma; Ahmed, Nirmeen; Ezz, Sara; Ashraf, Nouran; Ibrahim, Shaimaa S;
Abstract
The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main epilepsy pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, and neuroinflammation.
Other data
| Title | Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway | Authors | George, Mina Y. ; El-Derany, Marwa O; Ahmed, Yasmine; Zaher, Malvina; Ibrahim, Caroline; Waleed, Habiba; Khaled, Hajar; Khaled, Gehad; Saleh, Ahmed; Alshafei, Huda; Alshafei, Rahma; Ahmed, Nirmeen; Ezz, Sara; Ashraf, Nouran; Ibrahim, Shaimaa S | Keywords | AMPK/SIRT-1/PGC-1α;chrysin;microglia polarization;nanoemulsion;oxidative stress;status epilepticus | Issue Date | Jan-2023 | Publisher | TAYLOR & FRANCIS LTD | Journal | Expert opinion on drug delivery | Volume | 20 | Issue | 1 | Start page | 159 | End page | 174 | ISSN | 1742-5247 | DOI | 10.1080/17425247.2023.2153831 | PubMed ID | 36446395 | Scopus ID | 2-s2.0-85144151875 | Web of science ID | WOS:000898920100001 |
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