Spectroscopic, DFT analysis, antimicrobial and cytotoxicity studies of three gold(III) complexes
Ramadan, Ramadan M.; Noureldeen, AFH; Abo-Aly, M.M.; El-Medani SM;
Abstract
Three gold(III) complexes were synthesized using 2-pyrazinecarboxamide, pyridine or bipyridine ligand. Complexes were characterized by spectroscopic and analytical techniques (IR, Raman, 1H NMR, mass spectrometry and elemental analysis). Thermogravimetry and conductivity of complexes were investigated. IR, Raman and theoretical calculations of spectral modes of vibrations using DFT and MP2 methods were performed. Biological activities of the complexes against two bacteria Escherichia coli and Staphylococcus aureus and two fungi Aspergillus flavus and Candida albicans were screened. They exhibited activities toward both bacteria and fungi. Potency assays of the complexes against two breast cancer and liver carcinoma cell lines were evaluated. They exhibited in vitro activities toward the tumors relative to cis-platin. In addition, fluorescence quenching studies viscosity measurements of the complexes are performed. Theoretical calculations based on accurate DFT were established to verify the optimized structures of complexes. Global chemical reactivity descriptors were estimated from energy of HOMO and LUMO orbitals.
Other data
Title | Spectroscopic, DFT analysis, antimicrobial and cytotoxicity studies of three gold(III) complexes | Authors | Ramadan, Ramadan M. ; Noureldeen, AFH; Abo-Aly, M.M. ; El-Medani SM | Keywords | Pyrazine derivatives;gold complexes;IR and Raman studies;DFT studies;anticancer drugs | Issue Date | 2022 | Publisher | TAYLOR & FRANCIS INC | Journal | INORGANIC AND NANO-METAL CHEMISTRY | Volume | 52 | Issue | 2 | Start page | 213 | End page | 225 | ISSN | 2470-1556 | DOI | 10.1080/24701556.2021.1891102 | Scopus ID | 2-s2.0-85123561535 | Web of science ID | WOS:000626073100001 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.