Conventional and Microwave Synthesis of Some New Pyridine Derivatives and Evaluation Their Antimicrobial and Cytotoxic Activities
Kurls Ekram Anwer; Sayed, GH; Hassan, H.H.; Azab, ME;
Abstract
THE NEWLY synthesized compounds based on 2-amino-6-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)nicotinonitrile 1. The reactivity of pyridine derivative 1 was studied towards different reagents by its reaction with malononitrile, 2-(4-chlorobenzylidene) malononitrile, ethyl cyanoacetate, cyano acetic acid, m-nitro benzaldehyde, sodium azide, formamide, acetic anhydride and/or acetic anhydride/H2SO4 to give compounds 2-5,7, 10-13, respectively. The reaction of 5 with acetyl acetone gave the bipyridine derivative 6, while reaction of compound 7 with chloroacetyl chloride and phenacyl bromide gave the azetidinone derivatives 8 and 9. The formimidate 14 were obtained via reaction of compound 1 with triethylorthoformate, while reaction of 14 with phenylene diamine and/or acetamide gave the formimidamide and pyridopyrimidine derivatives 15 and 16 respectively. Compound 1 was also allowed to react with urea, thiourea, phthalic anhydride, succinic anhydride, benzoyl chloride, chloroacetonitrile, chloroacetyl chloride, p-toluenesulfonylchloride and ethyl bromoacetate to give compounds 17a,b - 24. Reaction of compound 1 with dichloro reagents in 1:1 ratio gave the bicyclic derivatives 25a–c, while its reaction with oxalyl chloride, dichloro and tetrachlorobenzoquinone derivatives, and/or dichloronaphthoquinone gave the imidazopyridine derivatives 26-29. Reaction of compound 29 with o-phenylenediamine in 1:2 ratio afforded the di-condenesed product 30 while, reaction of compound 1 with dichlororeagents in 1:2 ratio gave the polyalkyl derivatives 31a-b. The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and mass spectra. On the other hand the antimicrobial and anticancer activities of some of the newly synthesized compounds were studied and evaluated.
Other data
Title | Conventional and Microwave Synthesis of Some New Pyridine Derivatives and Evaluation Their Antimicrobial and Cytotoxic Activities | Authors | Kurls Ekram Anwer ; Sayed, GH; Hassan, H.H. ; Azab, ME | Keywords | Pyridine;One pot condensation;Naphthyridine;Pyrimidine;Imidazole;Antimicrobial;Anticancer;Microwave irradiation;ANTICANCER | Issue Date | 2019 | Publisher | NATL INFORM & DOCUMENT CENTRE | Journal | Egyptian Journal of Chemistry | Volume | 62 | Issue | 4 | Start page | 707 | End page | 726 | ISSN | 0449-2285 | DOI | 10.21608/EJCHEM.2018.5115.1452 | Scopus ID | 2-s2.0-85067197639 | Web of science ID | WOS:000473735600010 |
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