The Reformatsky analogous reaction for the synthesis of novel β-thioxoesters via using aroyl isothiocyanates under solvent-free ball milling and conventional conditions
Soliman Farag Saad, Paula; Hemdan, Magdy M.; Hassaballah, Aya I;
Abstract
The classical Reformatsky reaction, initially described in 1887, is considered one of the most useful ways of
forming C–C bonds. The target of this work includes improving the Reformatsky reaction between aroyl
isothiocyanates and a-haloesters using metallic zinc to form b-thioxoesters (3–11). In this procedure,
a new metal-mediated carbon–carbon linkage is formed with the formation of an organozinc halide and
decomposition due to the presence of dilute acid, affording a good yield of the desired product via
conventional techniques and ball milling. The Reformatsky reaction requires no solvent and no inert gases
forming C–C bonds. The target of this work includes improving the Reformatsky reaction between aroyl
isothiocyanates and a-haloesters using metallic zinc to form b-thioxoesters (3–11). In this procedure,
a new metal-mediated carbon–carbon linkage is formed with the formation of an organozinc halide and
decomposition due to the presence of dilute acid, affording a good yield of the desired product via
conventional techniques and ball milling. The Reformatsky reaction requires no solvent and no inert gases
Other data
Title | The Reformatsky analogous reaction for the synthesis of novel β-thioxoesters via using aroyl isothiocyanates under solvent-free ball milling and conventional conditions | Authors | Soliman Farag Saad, Paula ; Hemdan, Magdy M. ; Hassaballah, Aya I | Issue Date | 2022 | Publisher | Royal Society of Chemistry | Journal | RSC Advances | DOI | 10.1039/d2ra01154a |
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