G protein-coupled estrogen receptor (GPER) selective agonist G1 attenuates the neurobehavioral, molecular and biochemical alterations induced in a valproic acid rat model of autism
Hameed, Rehab Abdel; Ahmed, Emad; Mahmoud, Asmaa A; Atef, Azza A;
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a rising prevalence in boys rather than girls. G protein-coupled estrogen receptor (GPER) activation by its agonist G1 showed a neuroprotective effect, similar to estradiol. The present study aimed to examine the potential of the selective GPER agonist G1 therapy on the behavioral, histopathological, biochemical, and molecular alterations induced in a valproic acid (VPA)-rat model of autism.
Other data
| Title | G protein-coupled estrogen receptor (GPER) selective agonist G1 attenuates the neurobehavioral, molecular and biochemical alterations induced in a valproic acid rat model of autism | Authors | Hameed, Rehab Abdel; Ahmed, Emad ; Mahmoud, Asmaa A; Atef, Azza A | Keywords | Aromatase;Autism;G1;GPER;RORα;VPA | Issue Date | 16-Jun-2023 | Journal | Life Sciences | Volume | 328 | ISSN | 00243205 | DOI | 10.1016/j.lfs.2023.121860 | PubMed ID | 37331505 |
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