The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study
Khella, Mina; Salem, Ahmed M; Abdel-Rahman, Omar; Saad, Amr Shafik;
Abstract
Despite the established link between malignant pleural mesothelioma (MPM) and asbestos exposure, genetic risk factors may play a key role in MPM pathogenesis. The rs9939609 polymorphism in the FTO gene has recently been implicated as a risk factor for some types of cancer, such as breast, pancreatic, and prostate cancers. FTO variation is associated with altered adipocytokine expression and oxidative stress inflammation, which may influence asbestos mediated-carcinogenesis. This is the first study to investigate a possible association between this polymorphism and MPM risk.
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| Title | The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study | Authors | Khella, Mina ; Salem, Ahmed M ; Abdel-Rahman, Omar ; Saad, Amr Shafik | Keywords | FTO;association;cancer;genotyping;mesothelioma;polymorphism | Issue Date | Feb-2018 | Journal | Genetic testing and molecular biomarkers | Volume | 22 | Issue | 2 | ISSN | 19450265 | DOI | 10.1089/gtmb.2017.0146 | PubMed ID | 29260910 | Scopus ID | 2-s2.0-85041706125 |
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