Overexpression of BAMBI and SMAD7 impacts prognosis of acute myeloid leukemia patients: A potential TERT non-canonical role
Magdy Shehata, Miral; Sallam, Al-Aliaa Mohamed; Naguib, Mary Gamal; El-Mesallamy, Hala Osman;
Abstract
Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and mothers against decapentaplegic homolog 7 (SMAD7) are important transforming growth factor-β (TGF-β) signaling antagonists, however their roles in acute myeloid leukemia (AML) remains unclear. Telomerase reverse transcriptase (TERT) may be involved in regulating BAMBI and SMAD7 expressions; a role beyond telomeres that is not clinically validated yet.
Other data
| Title | Overexpression of BAMBI and SMAD7 impacts prognosis of acute myeloid leukemia patients: A potential TERT non-canonical role | Authors | Magdy Shehata, Miral ; Sallam, Al-Aliaa Mohamed; Naguib, Mary Gamal; El-Mesallamy, Hala Osman | Keywords | Acute myeloid leukemia;BAMBI;SMAD7;TERT;transforming growth factor-β | Issue Date | 2021 | Journal | Cancer biomarkers : section A of Disease markers | Volume | 31 | Issue | 1 | Start page | 47 | End page | 58 | ISSN | 15740153 | DOI | 10.3233/CBM-200927 | PubMed ID | 33780363 | Scopus ID | 2-s2.0-85106940895 |
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