Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity
Madkour, Mohamed I.; Rasha Elsherif Hassan; Sherif, Naglaa M.; Awadallah, Samir; Abdelrahim, Dana N.; Jahrami, Haitham A.; Abu Shihab, Katia; Faris, Moez Al Islam E.;
Abstract
Aims: Haptoglobin (Hp) is a multifaceted marker of inflammation, and mediates the interplay between obesity, inflammation, and cardiometabolic dysfunction. However, the role of the Hp phenotype in modulating intermittent fasting (IF)-induced cardiometabolic changes remains to be elucidated. Methods: Hp phenotype was determined for the study subjects. Cardiometabolic markers were assessed before and at the end of four consecutive weeks, dawn to sunset IF. Results: A total of 114 subjects (75 males and 39 females, 38.7 ± 11.7 years, body mass index (BMI) of 30.41 ± 5.09 kg/m2) were recruited. Hp2-2 (n = 55, 48.2 %) and Hp2-1 (n = 53, 46.5 %) were the predominant phenotypes. Significant reductions were observed in serum Hp, IL-6, TNF-α, triglycerides (TG), total cholesterol (TC), LDL, BMI, and fat mass (FM), while a significant elevation was observed in serum CD163, HDL, and IL-10 at the end of the IF month for the whole population. Based on the Hp polymorphism, significant decreases in Hp, BMI, FM, TG, LDL, and TNF-α, with significant increases in HDL and CD163 levels were observed among subjects with Hp2-2 and Hp2-1 phenotypes. A more pronounced reduction in FM was reported in subjects with Hp2-2 in comparison with Hp2-1. Conclusion: Hp gene polymorphism modulates IF-induced changes in cardiometabolic markers. Clinical Trial Registration number: ISRCTN18205186; https://trialsearch.who.int/?TrialID=ISRCTN18205186.
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Title | Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity | Authors | Madkour, Mohamed I.; Rasha Elsherif Hassan ; Sherif, Naglaa M.; Awadallah, Samir; Abdelrahim, Dana N.; Jahrami, Haitham A.; Abu Shihab, Katia; Faris, Moez Al Islam E. | Keywords | Inflammation;Nucleotide Polymorphisms (SNPs);Oxidative stress;Nutrigenomics;Personalized nutrition;Time-restricted eating | Issue Date | 1-Aug-2022 | Journal | Diabetes research and clinical practice | Volume | 190 | ISSN | 01688227 | DOI | 10.1016/j.diabres.2022.110024 | PubMed ID | 35905889 | Scopus ID | 2-s2.0-85135935694 |
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