Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study

El-Derany, Marwa O; Hanna, Diana M F; Youshia, John; Elmowafy, Enas; Farag, Mohamed A.; Azab, Samar S;


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the increasing proportion of nano-based vaccines, this review compiles and analyses how COVID-19 and nanoparticles affect lipids, amino acids, and carbohydrates metabolism. A search was conducted on PubMed, ScienceDirect, Web of Science for available information on the interrelationship between metabolomics and immunity in the context of SARS-CoV-2 infection and the effect of nanoparticles on metabolite levels. It was clear that SARS-CoV-2 disrupted several pathways to ensure a sufficient supply of its building blocks to facilitate its replication. Such information can help in developing treatment strategies against viral infections and COVID-19 based on interventions that overcome these metabolic changes. Furthermore, it showed that even drug-free nanoparticles can exert an influence on biological systems as evidenced by metabolomics.

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Title Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Authors El-Derany, Marwa O; Hanna, Diana M F; Youshia, John ; Elmowafy, Enas; Farag, Mohamed A. ; Azab, Samar S
Keywords COVID-19;Metabolomics;Nanoparticles;SARS-CoV-2;Viral infections
Issue Date Oct-2023
Publisher Springer Nature
Journal Pharmacological Reports 
Volume 75
Start page 1045
End page 1065
ISSN 1734-1140
DOI 10.1007/s43440-023-00517-w
PubMed ID 37587394

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