Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy
Magdy, Yosra M; El-Kharashi, Omnyah A; Alaa El Din Aly El Waseef, Dalia; Nabih, Enas S; Abd El Samad, Abeer A;
Abstract
The repression of renal Farnesoid X Receptor (FXR) had been shown to result from lack of bile acid production from cirrhotic liver. We hypothesized that silymarin and rosuvastatin (Rvs) could have a hepatorenal therapeutic effects in hepatic nephropathy through induction of FXR.
Other data
| Title | Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy | Authors | Magdy, Yosra M; El-Kharashi, Omnyah A; Alaa El Din Aly El Waseef, Dalia ; Nabih, Enas S; Abd El Samad, Abeer A | Keywords | Cirrhosis;DDAH-1;FXR;Kidney;Rosuvastatin;Silymarin | Issue Date | Dec-2018 | Journal | Experimental and molecular pathology | Volume | 105 | Issue | 3 | Start page | 293 | End page | 310 | ISSN | 00144800 | DOI | 10.1016/j.yexmp.2018.10.004 | PubMed ID | 30308196 | Scopus ID | 2-s2.0-85054556948 |
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