Evaluation of serum visfatin level and its relation to insulin resistance in patients with inflammatory acne vulgaris

Abstract

Acne vulgaris is one of the most common dermatological diseases worldwide. Several pathogenic mechanisms were evaluated for its role in the pathogenesis of acne. Psychological stress, hormonal imbalance, disturbed serum lipid profile and genetic factors were all implicated in acne development. Involvement of immune system and novel adipokines were recently linked to acne vulgaris pathogenesis. Serum visfatin, also known as Nicotinamide phosphoribosyl transferase, is an adipokine that participates in several biologic process as inflammation and apoptosis. Moreover, visfatin possess a pivotal role in various inflammatory diseases either systemic or dermatological. Visfatin exerts several roles in the pathogenesis of insulin resistance, obesity and therefore was linked to development of inflammatory acne vulgaris.