Possible Ameliorative Role of Curcumin on Macrophage Expression and Activation in Adjuvant Induced Arthritis
Mohammed Hazem Majeed Al-Doori;
Abstract
The present study was established to determine the ameliorative role of Curcumin on initiated side effects of Methotrexate. Also, to explore the potential mechanisms of anti-inflammatory activity of Curcumin on macrophage polarization, expression, activation and cytokines secretion.
Eighty male albino rats (130-150g) were divided into eight groups:
9. Group one served as a control group (C), and left without treatment.
10. Group two, Methotrexate group (MTX), was injected intraperitoneally (IP) with Methotrexate in a dose of 0.75 mg/kg b.w./week for 20 days (Baggott and Morgan, 2007).
11. Group three, Curcumin group (CUR), was treated with a daily oral dose of Curcumin (150 mg/kg b.w./day) for 20 days (Somasundaram et al., 2014).
12. Group four, both Methotrexate and Curcumin group (MTX + CUR), was treated with Methotrexate accompanied with Curcumin as the same previous corresponding doses, period and route of administration.
13. Group five, Adjuvant arthritis (AIA) group, was injected with Complete Freund’s adjuvant for arthritis induction and kept without treatment.
14. Group six, (AIA/MTX), arthritis induction then treated with Methotrexate as the same previous dose, period and route of administration.
Eighty male albino rats (130-150g) were divided into eight groups:
9. Group one served as a control group (C), and left without treatment.
10. Group two, Methotrexate group (MTX), was injected intraperitoneally (IP) with Methotrexate in a dose of 0.75 mg/kg b.w./week for 20 days (Baggott and Morgan, 2007).
11. Group three, Curcumin group (CUR), was treated with a daily oral dose of Curcumin (150 mg/kg b.w./day) for 20 days (Somasundaram et al., 2014).
12. Group four, both Methotrexate and Curcumin group (MTX + CUR), was treated with Methotrexate accompanied with Curcumin as the same previous corresponding doses, period and route of administration.
13. Group five, Adjuvant arthritis (AIA) group, was injected with Complete Freund’s adjuvant for arthritis induction and kept without treatment.
14. Group six, (AIA/MTX), arthritis induction then treated with Methotrexate as the same previous dose, period and route of administration.
Other data
| Title | Possible Ameliorative Role of Curcumin on Macrophage Expression and Activation in Adjuvant Induced Arthritis | Other Titles | الدور المحسن المحتمل للكركومين على تعبير وتنشيط الخلايا البلعمية فى إلتهاب المفاصل المحدث بالأدجوفند | Authors | Mohammed Hazem Majeed Al-Doori | Issue Date | 2022 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB12668.pdf | 2.53 MB | Adobe PDF | View/Open |
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