A Prospective Clinical Study of the Effect of Recombinant Human Growth Hormone in Wound Healing of Severely Burned Children

Abstract

Aburn is a thermal injury caused by biological, chemical, electrical and physical agents with local and systemic repercussions. There are several ways of classifying burns: Classification by mechanism, cause, Classification by the degree and depth of a burn, and extent of burn. There are more than 300,000 deaths worldwide due to a burn insult. Over the last 40 years burn outcomes improved dramatically, due to establishing specialized burn centers and profound advances in therapy strategies. However, severe burns remain an injury that affects nearly every organ system and that leads to a significant morbidity and mortality. Deaths in burn patients generally occur either immediately after the injury or weeks later as a result of infection/sepsis, multi-system organ failure or hypermetabolic catabolic responses.

The cause of death has been changed significantly in the last decade. Cause of death in severely burned patients used to be due to anoxic brain injury, followed by sepsis, and multi organ failure. Nowadays the major cause of death in burned patients is sepsis followed by multi organ failure and anoxic brain injury.