Analysis of Serum Chemerin Level in Acanthosis Nigricans Patients: A Case Control Study

Abstract

canthosis nigricans (AN) describes clinically a darkly pigmented thickening skin, which demonstrates epidermal/dermal hyperplasia with orthokeratotic hyperkeratosis and papillomatosis of stratum spinosum with basal layer hyperpigmentation, in the absence of actual acanthosis and melanocytosis in histology. It is a reactive cutaneous change closely associated with obesity/ insulin resistance/ hyperinsulinemia, endocrinopathy, or malignancy in particular gastrointestinal adenocarcinoma. The prevalence varies, and ethnicity seems an independent factor. Evidence shows that AN is a useful clinical marker to identify patients susceptible to insulin resistance, the metabolic syndrome, and type 2 diabetes (Karada˘g et al., 2017).