Thyroid Function Hormones Profile in Acute Stroke Patients

Abstract

Cerebrovascular stroke is the third commonest cause of mortality worldwide and a major cause of long-term disability. Perturbations in the hypothalamus- pituitary-thyroid (HPT) axis affect stroke risk and stroke outcomes. Hypothyroidism can cause hypertension, hypercholesterolemia, cardiac dysfunction, and both hypo- and hypercoagulability, all of which are risk factors for stroke. This study was conducted on 101 acute ischemic stroke patients who were admitted to the neurology department of Nasser institute hospital. All the patients were evaluated by measuring the thyroid hormone level, NIHSS, and mRS and performing CT, MRI-brain, echocardiography and carotid duplex that will be discussed afterward, in addition to the rest of the stroke protocol that was done routinely to every patient who admitted to the hospital. We also measured the thyroid hormone levels, NIHSS, and mRS after one month of follow up. The current study included 101 ischemic stroke patients as a random sample, ranged from 18 to 80 years-old with mean age ±SD 63.6 ± 12.4, and showed males percentage of 56.4%. The most prevalent risk factors were HTN in 74 patients (73.3%) and DM in 54 patients (53.5%). Regarding to study group comparison between normal and abnormal thyroid groups in our study stroke patients related to demographic and base line clinical factors profiles, there was significant difference between the two groups (P < 0.05) in the distribution of sex, HTN and AF. The comparison between normal and abnormal thyroid groups on our study stroke patients related to other factors profiles as TOAST criteria, ECHO, carotid stenosis and site of infarction didn`t show any significant difference between the two groups (P> 0.05).