Antibacterial activity of probiotics and bacteriophages with detection of the role of probiotics in metabolic disorders improvement

Abstract

Diabetic foot infections (DFIs) have become one of the most important and growing public health concerns that are more difficult to treat in diabetic patients. DFIs not only extend the average length of the hospital stay, resulting in a huge economic burden but also increase the risk of amputation. Pseudomonas aeruginosa is one of the most important opportunistic pathogenic bacterium in the diabetic foot that should never be ignored. It can be responsible for a spectrum of severe complications from superficial colonization of diabetic foot ulcers to extensive tissue damage, including osteomyelitis, septic arthritis, bacteremia and amputation. One of the challenges in managing P. aeruginosa infections is its multiple resistant to the most commonly used antibiotics and possession of virulence factors. Antimicrobial resistance in bacterial pathogens is a significant challenge that considered the main cause of morbidity and mortality in infected patients. Due to challenges associated with the antimicrobial resistance in bacterial infections and associated diseases in addition to lack of new antibiotics, development of novel effective treatment options and alternative antimicrobial therapies are now highly required.