Local Recurrence of Phyllodes Tumors of the Breast: A Meta-Analysis

Abstract

Phyllodes tumors of the breast are typically large, rapidly growing tumors that account for up to 1% of all breast neoplasms. The World Health Organization classifies phyllodes tumors into three histologic subtypes: benign, borderline, and malignant, based on stromal cellularity, stromal cell mitotic activity, stromal nuclear atypia, stromal overgrowth and type of borders (infiltrating or pushing) (Chao et al., 2019). Review: Phyllodes tumors have a low incidence (1 in 100,000 women) and account for only 0.5% of all breast neoplasms. The majority of these tumors arise in women aged 35–55 years (approximately 20 years later compared to fibroadenomas). In men, phyllodes tumors are very rare, with only few cases described to date (ZeNG et al., 2015). It has a distinct biphasic characteristics of fibroepithelial diseases namely epithelial and stromal components. In a phyllodes tumour, there is evidence of stromal overgrowth rather than epithelial elements. Presence of an epithelial component differentiates phyllodes tumor from other stromal sarcomas (Hayati et al., 2017). The majority of these tumors are benign (35-64%), and the rest are divided into borderline and malignant subtypes. Altho